Without natural affection - see the notes at Romans 1:31.

Trucebreakers - The same word in Romans 1:31, is rendered "implacable;" see the notes at that verse. It properly means "without treaty;" that is, those who are averse to any treaty or compact. It may thus refer to those who are unwilling to enter into any agreement; that is, either those who are unwilling to be reconciled to others when there is a variance - implacable; or those who disregard treaties or agreements. In either case, this marks a very corrupt condition of society. Nothing would be more indicative of the lowest state of degradation, than that in which all compacts and agreements were utterly disregarded.

False accusers - Margin, "makebates." The word "makebate" means one who excites contentions and quarrels. Webster. The Greek here is διάβολοι diaboloi - "devils" - the primitive meaning of which is, "calumniator, slanderer, accuser;" compare the notes at 1 Timothy 3:11, where the word is rendered "slanderers."

Incontinent - 1 Corinthians 7:5. Literally, "without strength;" that is, without strength to resist the solicitations of passion, or who readily yield to it.

Fierce - The Greek word used here - ἀνήμερος anēmeros - does not elsewhere occur in the New Testament. It means "ungentle, harsh, severe," and is the opposite of gentleness and mildness. Religion produces gentleness; the want of it makes men rough, harsh, cruel; compare the notes at 2 Timothy 2:24.

Despisers of those that are good - In Titus 1:8, it is said of a bishop that he must be "a lover of good men." This, in every condition of life, is a virtue, and hence, the opposite of it is here set down as one of the characteristics of that evil age of which the apostle speaks.

2 Timothy 3:3 Parallel Commentaries

Appendix i. Pseudepigraphic Writings
III. The collection of eighteen hymns, which in their Greek version bear the name of the Psalter of Solomon, must originally have been written in Hebrew, and dates from more than half a century before our era. They are the outcome of a soul intensely earnest, although we not unfrequently meet expressions of Pharisiac self-religiousness. [6315] It is a time of national sorrow in which the poet sings, and it almost seems as if these Psalms' had been intended to take up one or another of the leading …
Alfred Edersheim—The Life and Times of Jesus the Messiah

Enmity Between Man and Satan
"I will put enmity between thee and the woman, and between thy seed and her seed; it shall bruise thy head, and thou shalt bruise his heel." Genesis 3:15. The divine sentence pronounced against Satan after the fall of man was also a prophecy, embracing all the ages to the close of time and foreshadowing the great conflict to engage all the races of men who should live upon the earth. God declares: "I will put enmity." This enmity is not naturally entertained. When man transgressed the divine law, …
Ellen Gould White—The Great Controversy

Letter xxii (Circa A. D. 1129) to Simon, Abbot of S. Nicholas
To Simon, Abbot of S. Nicholas Bernard consoles him under the persecution of which he is the object. The most pious endeavours do not always have the desired success. What line of conduct ought to be followed towards his inferiors by a prelate who is desirous of stricter discipline. 1. I have learned with much pain by your letter the persecution that you are enduring for the sake of righteousness, and although the consolation given you by Christ in the promise of His kingdom may suffice amply for …
Saint Bernard of Clairvaux—Some Letters of Saint Bernard, Abbot of Clairvaux