4:11 And now art thou cursed from the earth -
1. He is cursed, separated to all evil, laid under the wrath of God, as it is revealed from heaven against all ungodliness and unrighteousness of men.
2. He is cursed from the earth. Thence the cry came up to God, thence the curse came up to Cain. God could have taken vengeance by an immediate stroke from heaven: but he chose to make the earth the avenger of blood; to continue him upon the earth, and not presently to cut him off; and yet to make even that his curse. That part of it which fell to his share, and which he had the occupation of, was made unfruitful, by the blood of Abel. Besides, A fugitive and a vagabond shalt thou be in the earth. By this he was here condemned, to perpetual disgrace and reproach, and to perpetual disquietment and horror in his own mind. His own guilty conscience should haunt him where ever he went. Now to justify his complaint, Observe his descants upon the sentence. He sees himself excluded by it from the favour of his God; and concludes, that being cursed, he was hid from God's face, and that is indeed the true nature of God's curse; damned sinners find it so, to whom it is said, Depart from me ye cursed. Those are cursed indeed that are for ever shut out from God's love and care, and from all hopes of his grace. He sees himself expelled from all the comforts of this life; and concludes, Ge 4:14. Thou hast driven me out this day from the face of the earth - As good have no place on earth as not have a settled place. Better rest in the grave than not rest at all. And from thy face shall I be hid - Shut out of the church, not admitted to come with the sons of God to present himself before the Lord. And it shall come to pass that every one that finds me shall slay me - Wherever he wanders he goes in peril of his life. There were none alive but his near relations, yet even of them he is justly afraid, who had himself been so barbarous to his own brother.

Genesis 4:11 Parallel Commentaries

How the Kindly-Disposed and the Envious are to be Admonished.
(Admonition 11.) Differently to be admonished are the kindly-disposed and the envious. For the kindly-disposed are to be admonished so to rejoice in what is good in others as to desire to have the like as their own; so to praise with affection the deeds of their neighbours as also to multiply them by imitation, lest in this stadium of the present life they assist at the contest of others as eager backers, but inert spectators, and remain without a prize after the contest, in that they toiled not …
Leo the Great—Writings of Leo the Great

Epistle cxxii. To Rechared, King of the visigoths .
To Rechared, King of the Visigoths [82] . Gregory to Rechared, &c. I cannot express in words, most excellent son, how much I am delighted with thy work and thy life. For on hearing of the power of a new miracle in our days, to wit that the whole nation of the Goths has through thy Excellency been brought over from the error of Arian heresy to the firmness of a right faith, one is disposed to exclaim with the prophet, This is the change wrought by the right hand of the Most High (Ps. lxxvi. 11 [83] …
Saint Gregory the Great—the Epistles of Saint Gregory the Great

The Growth of the Old Testament Prophetic Histories
[Sidenote: Analogies between the influences that produced the two Testaments] Very similar influences were at work in producing and shaping both the Old and the New Testaments; only in the history of the older Scriptures still other forces can be distinguished. Moreover, the Old Testament contains a much greater variety of literature. It is also significant that, while some of the New Testament books began to be canonized less than a century after they were written, there is clear evidence that …
Charles Foster Kent—The Origin & Permanent Value of the Old Testament